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As an effective, highly specific, and irreversible inhibitor of ODC, DFMO can inhibit tumor growth by promoting the consumption of putrescine and spermidine [294]
The treatment schedule is shown in Fig
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Notably, most clinical investigations studied women (1404 female versus 83 male participants), which is expected since estrogen declines after age 30 years, and further estrogen decline with aging represents health challenges, as well as a reduction in QOL [9, 10, 19,20,21,22] and a degradation in the most visible organ of the bodythe skin [9, 10]
trials extended to 48 weeks [3] [4]
S., Mueckler, M
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